4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID

4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID - Names and Identifiers

Name	(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)boronic acid
Synonyms	4-[(N-BOC-Amino)methyl]phenylboronicacid N-BOC-4-(AMINOMETHYL)BENZENEBORONIC ACID 4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID 4-(AMINOMETHYL)BENZENEBORONIC ACID, N-BOC PROTECTED 4-(TERT-BUTOXYCARBONYLAMINOMETHYL)PHENYLBORONIC ACID (4-{[(tert-Butoxycarbonyl)amino]methyl}phenyl)boronic acid (4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)boronic acid Carbamic acid, N-[(4-boronophenyl)methyl]-, 1,1-dimethylethyl ester [4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]boronic acid
CAS	489446-42-6
InChI	InChI=1/C12H18BNO4/c1-12(2,3)18-11(15)14-8-9-4-6-10(7-5-9)13(16)17/h4-7,16-17H,8H2,1-3H3,(H,14,15)

4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID - Physico-chemical Properties

Molecular Formula	C12H18BNO4
Molar Mass	251.09
Density	1.15±0.1 g/cm3(Predicted)
Melting Point	208-210°C
pKa	8.54±0.16(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.526

4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
Hazard Note	Irritant/Keep Cold

4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID - Reference Information

Use

4-(N-BOC-aminomethyl) Phenylboronic acid is an organic intermediate, it can be used for the preparation of 4-aminomethylphenylboronic acid compounds. 4-aminomethylphenylboronic acid compounds are one of the commonly used substrates in Suzuki reactions. They are often used in the synthesis of biphenyl compounds and widely used in the fields of pharmaceuticals, OLED materials and so on. In addition, 4-(N-BOC-aminomethyl) Phenylboronic acid can be used to prepare lipid pore-filled Silica Thin film membranes for simulating the recovery of diluted carbohydrates.

preparation

di-tert-butyl dicarbonate (G, 16mmol) and triethylamine (13ML, 9.4mmol) add to a stirred solution of 4-aminomethylphenylboronic acid (3G, 16mmol) in tetrahydrofuran (100ml). The reaction was stirred at reflux for 1 H, then the solvent was evaporated and the residue was partitioned between water and ethyl acetate. The organic phase was concentrated under reduced pressure to afford 4-(N-BOC-aminomethyl) Phenylboronic acid (2.67g,10.6mmol) as a white solid.

Last Update：2024-04-10 22:41:03